Protein Details: Store-operated calcium entry regulator STIMATE
Protein ID
ICDB_Pro_0934
Protein Name
Store-operated calcium entry regulator STIMATE
Gene Name
Stimate; Tmem110
Organism
Mus musculus (Mouse)
Length
288 amino acids
AlphaFoldDB
AF-Q3UF25-F1-model_v4.pdb
Function
Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM); called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1; promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.
Sequence
MQGPGGNVSRGLPSGPASTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVGVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNAFMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDAEEDLRRPVKKKHRFGLPV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Widely expressed.
DOI ID
10.1126/science.1112014; 10.1101/gr.2596504; 10.1038/ncb3234
RefSeq
NP_083115.3